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Per artursson cv. However, it is not clear whether relative differences in mRNA concentrations are retained on the protein level. Pharmacokinet. It is critical for gastrointestinal absorption, brain penetration, renal reabsorption, defining clearance mechanisms and drug-drug interactions. Traditionally, indirect or estimated cell permeability measurements such as estimations from logP or artificial m … Jul 10, 2025 · UDOPP is the DDD-platform unit for absorption, distribution, metabolism, excretion (ADME) and pharmaceutical profiling. A double-loop cross-validation (CV) procedure was used to provide an unbiased estimate of the prediction accuracy: model optimization was performed in a ten-fold inner CV loop, estimating model improvement based on the withheld data, and the prediction accuracy of the optimized models were estimated from the withheld data in the outer CV loop. Christel A. Complete player biography and stats. Biology and Biochemistry scholar academic profile. 44 (4): 1477-1488 (2004) 2003 [j1] view electronic edition via DOI unpaywalled version references & citations authority control: export Feb 22, 2017 · André Mateus, Andrea Treyer, Christine Wegler, Maria Karlgren, Pär Matsson & Per Artursson Cardiovascular and Metabolic Diseases Innovative Medicines, DMPK, AstraZeneca R&D, Mölndal, SE-431 83 Per Artursson, Patrik Lundquist Medicine Drug Pharmacokinetics DOI: 10. Per Artursson practices in Uppsala, Sweden. Kvitne KE, Åsberg A, Johnson LK, Wegler C, Hertel JK, Artursson P, Karlsson C, Andersson S, Sandbu R, Skovlund E, Christensen H, Jansson-Löfmark R, Hjelmesaeth J, Robertsen I. Impact of type 2 diabetes on in vivo activities and protein expressions of cytochrome P450 in patients with obesity. Wassvik, Ulf Norinder, Kristina Luthman, Per Artursson: Global and Local Computational Models for Aqueous Solubility Prediction of Drug-Like Molecules. In Focus 👉 Per Artursson, Professor of Dosage Form Design, that 48 years, 335 publications and 35,700 citations after he first enrolled at Uppsala University… | 13 comments on LinkedIn Oct 19, 2020 · Passive permeability is a key property in drug disposition and delivery. Bergström a , Kristina Luthman b , Per Artursson a Show more Add to Mendeley Cite Article Full-text available Jan 2021 Magnus Ölander Christine Wegler Inken Flörkemeier [] Per Artursson Mar 4, 2024 · The development of pediatric oral drugs is hampered by a lack of predictive simulation tools. Lataa offline-lukemista varten, korosta, lisää Abstract Permeability coefficients across monolayers of the human colon carcinoma cell line Caco-2, cultured on permeable supports, are commonly used to predict the absorption of orally administered drugs and other xenobiotics. Feb 25, 2024 · We assessed the performance of ten different 384- and 96-well ultra-low attachment (ULA) microplates in facilitating three-dimensional spheroid culture of primary human hepatocytes (PHH) and primary This issue of the Journal of Pharmaceutical Sciences is dedicated to Professor Per Artursson and the groundbreaking contributions he has made and continues to make in the Pharmaceutical Sciences. Importantly, these citations are distributed over the numerous fields This edition of the Journal of Pharmaceutical Sciences is dedicated to the wonderful career of Per Artursson from the Uppsala University. Two especially influential papers have been cited more t … Oct 30, 2019 · Genes and proteins show variable expression patterns throughout the human body. Passive diffusion rate is translatable across tissues and animal species, while th … Per Artursson is professor in Dosage Form Design at the Department of Pharmacy, Uppsala University, Sweden where he heads the Drug Delivery research team. Jan 1, 2021 · This issue of the Journal of Pharmaceutical Sciences is dedicated to Professor Per Artursson and the groundbreaking contributions he has made and continues to make in the Pharmaceutical Sciences. He is also Director of the Uppsala University drug optimization and pharmaceutical profiling platform within Science for Life Laboratories. Importantly, these citations are distributed over the numerous fields Read articles by Per E. com hockey player profile of Per Artursson, 1968-04-24 Sweden. se stefan. Eliteprospects. Per Artursson is the author of Drug Bioavailability (0. 0 avg rating, 0 ratings, 0 reviews, published 2006), Drug Bioavailability (0. Per is one of the most cited researchers in his field, with more than 30,000 citations and an h-index of 95 as of September 2020. His top areas of expertise are Obesity, Colorectal Cancer, and Gastric Bypass. 1124/dmd. In ulcerative colitis (UC), a chronic inflammatory bowel disease, this barrier function is impaired leading to an abnormal immune response and inflammation of the colonic mucosa. 2022;23:7468. Brayden ,Journal of Pharmaceutical Sciences,发表年份:2021 , 被引用:2. , Discover Per Artursson's known position history, network and 5 relationships. … Discover the latest information about Per Artursson - D-Index & Metrics, Awards, Achievements, Best Publications and Frequent Co-Authors. Chem. The same text also describes the adult professional's uninterrupted search for new scientific horizons. Influence of hepatic blood flow, plasma and blood cell Artursson, P. However, it is not clear if these zonal size differences, and the associated phenotypic differences, are retained in isolated human hepatocytes, t … Jan 20, 2025 · In Focus Per Artursson, Professor of Dosage Form Design, that 48 years, 335 publications and 35,700 citations after he first enrolled at Uppsala The series editors would like to thank Han van de Waterbeemd, Hans Lennerna ̈s, and Per Artursson for their enthusiasm to put together this book and to work with such a fine selection of authors. His research aims at understanding drug absorption, distribution, metabolism and elimination (ADME) at the molecular and cellular level in order to deliver drugs more effectively via the oral Feb 22, 2017 · Intracellular drug exposure is influenced by cell- and tissue-dependent expression of drug-transporting proteins and metabolizing enzymes. Download for offline reading, highlight, bookmark or take notes while you read Drug Bioavailability Per Artursson's Major Contributions to the Caco-2 Cellular Novels throughout Prescription Sciences. Drug Bioavailability: Estimation of Solubility, Permeability, Absorption and Bioavailability - Ebook written by Han van de Waterbeemd, Hans Lennernäs, Per Artursson, Raimund Mannhold, Hugo Kubinyi, Gerd Folkers. Most recently in the Division 4 with Nynäshamns IF 2. As a result, 3D PHH are gaining importance as a model for mechanistic liver homeostasis studies and in vitro to in vivo extr … Overall, the data we provide constitute a unique resource for exploring the proteomes of the major types of human liver cells, which will facilitate an improved understanding of the human liver in health and disease. First, the molecular constraints to peptide … Eliteprospects. In turn, each of these segments was used as hold-out prediction sets, while the compounds in the remaining nine segments were used for model training. S. Furthermore, inter-individual protein concentration variability within single tissue types has not been comp … Overall, the data we provide constitute a unique resource for exploring the proteomes of the major types of human liver cells, which will facilitate an improved understanding of the human liver in health and disease. These tools, in turn, require data on the physiological variables that influence oral drug absorption, including the expression of drug transporter proteins (DTPs) and drug-metabolizing enzymes (DMEs) in th … Jan 20, 2025 · In Focus Per Artursson, Professor of Dosage Form Design, that 48 years, 335 publications and 35,700 citations after he first enrolled at Uppsala The series editors would like to thank Han van de Waterbeemd, Hans Lennerna ̈s, and Per Artursson for their enthusiasm to put together this book and to work with such a fine selection of authors. Per Artursson is a professor in Dosage Form Design at the Department of Pharmacy, Uppsala University, Sweden, where he heads the Drug Delivery research team. This edition of the Journal of Pharmaceutical Sciences is dedicated to the wonderful career of Per Artursson from the Uppsala University. Here, Sep 30, 2022 · Med drygt 5 miljoner euro från Horizon Europé ska kunskapskonsortiet GENEGUT utveckla en RNA-baserad terapi mot inflammatorisk sjukdom i mag-tarmkanalen. J. Per Artursson and Stephen Tindal, will discuss some of the key considerations, strategies, and solutions available in the drug development of challenging molecules. Uppsala university - 인용 횟수 40,623번 Abstract This issue of the Journal of Pharmaceutical Sciences is dedicated to Professor Per Artursson and the groundbreaking contributions he has made and continues to make in the Pharmaceutical Sciences. uu. Both cellular systems are characterized by high inter- and intraindividual differences, but their impact on drug distribution and efficacy remains incompletely understood. 2 Department of Cell and Molecular Biology, Biomedical Center, Uppsala University, SE-751 24 Uppsala, Sweden. 0 avg rating, 0 ratin Experts, Prof. Chitosan as a nonviral gene delivery system. We discuss the opportunities and predictivity of various in vitro systems with special emphasis on human intestine in Ussing chambers. Importantly, these citations are distributed over the Loop is the open research network that increases the discoverability and impact of researchers and their work. Furthermore, inter-individual protein concentration variability within single tissue types has not been comp … Jul 27, 2024 · 3D spheroids of primary human hepatocytes (3D PHH) retain a differentiated phenotype with largely conserved metabolic function and proteomic fingerprint over weeks in culture. Artursson on ScienceDirect, the world's leading source for scientific, technical, and medical research. It requires determination of enzyme inhibition in vitro which is highly system-dependent for many compounds. Professor Per Artursson of the Department of Pharmacy has been named a Fellow of the American Association for the Advancement of Science (AAAS). 1 Department of Pharmacy, Uppsala University, Uppsala, Sweden. Read this book using Google Play Books app on your PC, android, iOS devices. Importantly, these citations are distributed over the numerous fields Loop is the open research network that increases the discoverability and impact of researchers and their work. R. Per Artursson at Lab Artursson, Uppsala Jan 1, 2021 · This issue of the Journal of Pharmaceutical Sciences is dedicated to Professor Per Artursson and the groundbreaking contributions he has made and continues to make in the Pharmaceutical Sciences. Per Artursson at Lab Artursson, Uppsala Per Artursson's Major Contributions to the Caco-2 Cell Literature in Pharmaceutical Sciences. Drug Bioavailability: Estimation of Solubility, Permeability, Absorption and Bioavailability – e-kirja kirjailijoilta Han van de Waterbeemd, Hans Lennernäs, Per Artursson, Raimund Mannhold, Hugo Kubinyi, Gerd Folkers. Aug 1, 2004 · Accuracy of calculated pH-dependent aqueous drug solubility☆ Christel A. Furthermore, inter-individual protein concentration variability Find Per Artursson's articles, email address, contact information, Twitter and more Dec 9, 2020 · The desire to follow and develop his thoughts and ideas has likely followed from a young age. per. Inténtalo de nuevo más tarde. Model. Jan 16, 2021 · Magnus Ölander, Christine Wegler, Andrea Treyer, Inken Flörkemeier, André Mateus, Jozef Urdzik, and Per Artursson analyzed and interpreted data. He is also Director of the Uppsala University Jan 20, 2025 · Hallå där… Per Artursson, professor i läkemedelsformulering, som 48 år, 335 publiceringar och 35 700 citeringar efter att han första gången skrev in sig vid Uppsala universitet gör sig redo att byta Biomedicinskt Centrum mot ett liv bland barnbarn och skidpister. Oral absorption of peptides and nanoparticles across the human intestine: Opportunities, limitations and studies in human tissues Article Aug 2016 Patrik Lundquist Per Artursson One of the key challenges facing early stage drug discovery is understanding the commonly observed difference between the activity of compounds in biochemical assays and cellular assays. 0: Navigating Drug Absorption and Delivery in the 3D frontier Brief CV Per Artursson is a professor in Dosage Form Design at the Department of Pharmacy, Uppsala University, Sweden, where he heads the Drug Delivery research team. Magnus Ölander and Per Artursson wrote the manuscript with input from all authors. Brief CV Per Artursson is a professor in Dosage Form Design at the Department of Pharmacy, Uppsala University, Sweden, where he heads the Drug Delivery research team. Jan 14, 2020 · News & Views Published: 14 January 2020 DRUG DELIVERY A new opening for orally taken peptide drugs Per Artursson & Patrik Lundquist Nature Biomedical Engineering 4, 12–13 (2020) Cite this article Aug 1, 2004 · Accuracy of calculated pH-dependent aqueous drug solubility☆ Christel A. artursson) on Instagram: "" This issue of the Journal of Pharmaceutical Sciences is dedicated to Professor Per Artursson and the groundbreaking contributions he has made and continues to make in the Pharmaceutical Sciences. ”Det inspirerar att anta en utmaning med så omfattande medicinska behov” konstaterar Per Artursson, professor i läkemedelsformulering. Intestinal permeability and solubility are two of the most important factors that determine the absorption properties of a compou … Feb 13, 2015 · 1 Department of Pharmacy and Science for Life Laboratories, Uppsala University, 751 23 Uppsala, Sweden. Box 580, SE-751 23 Uppsala, Sweden Notes The authors declare no competing financial interest. artursson@farmaci. M Köping-Höggård, I His research aims at understanding drug absorption, distribution, metabolism and elimination (ADME) at the molecular and cellular level in order to deliver drugs more effectively via the oral route. Importantly, these citations are distributed over the numerous elds he This edition of the Journal of Pharmaceutical Sciences is dedicated to the wonderful career of Per Artursson from the Uppsala University. This issue of the Journal of Pharmaceutical Sciences is dedicated to Professor Per Artursson and the groundbreaking contributions he has made and continues to make in the Pharmaceutical Sciences. Loop enables you to stay up-to-date with the latest discoveries and news, connect with researchers and form new collaborations. Apr 1, 2023 · A dynamic epithelium and a rich microbiota, separated by multi-layered mucus, make up the complex colonic cellular environment. . Per Artursson - Uppsala University Drug Optimization and Pharmaceutical Profiling Platform, Department of Pharmacy, Uppsala Biomedical Center, Uppsala University, P. Lue tämä kirja käyttämällä Google Play Kirjat ‑sovellusta tietokoneella tai Android- tai iOS-laitteella. Unquestionably, also an affirmation for recognizing Professor Per Artursson as one of the “TRUE GIANTS” in the pharmaceutical sciences. These tools, in turn, require data on the physiological variables that influence oral drug absorption, including the expression of drug transporter proteins (DTPs) and drug-metabolizing enzymes (DMEs) in th … Yoshimichi Sai, Yosuke Kaneko, Satsuki Ito, Keisuke Mitsuoka, Yukio Kato, Ikumi Tamai, Per Artursson, and Akira Tsuji Division of Pharmaceutical Sciences, Graduate Jun 18, 2019 · Accurate prediction of drug-drug interactions (DDI) is a challenging task in drug discovery and development. Bergström, Carola M. Uppsala university - 引用次数：41,822 次 0 Followers, 42 Following, 120 Posts - Per Artursson (@per. His clinical research consists of co-authoring 126 peer reviewed articles in the past 15 years. Identification of novel specific and general inhibitors of binding, and the hepatocellular enzymatic activity on hepatic drug the three major human ATP-binding cassette transporters P-gp, BCRP clearance. Two especially influential papers have been cited more than 1000 times out of a total citation count of almost 30,000 and a h-index of 93 (Google Jan 23, 2025 · The symposium will also honor Professor Per Artursson, SciLifeLab DDD scientific platform director, and his distinguished research career. The clinical development of new drugs is often terminated because of unfavourable pharmacokinetic properties such as poor intestinal absorption after oral administration. knight@icm. 作者: David J. 2 Science for Life Laboratory, Uppsala University, Uppsala, Sweden. PubMed Int J Mol Sci. 087940 Drug Metabolism and Disposition · 2020 Cited 10 times A Comparative Analysis of Cytochrome P450 Activities in Paired Liver and Small Intestinal Samples from Patients with Obesity Veronica Krogstad, Alexandra Peric, Ida Robertsen, Marianne Kristiansen Kringen, Christine Wegler, Philip Carlo Angeles Nov 15, 2016 · In this contribution, we review the molecular and physiological barriers to oral delivery of peptides and nanoparticles. Per currently We provide a short portrait of Per, with emphasis on his personality, driving forces and the inspirational sources that shaped his career as a world-leading scientist in the field. Most cited papers deals with absorption prediction. Professor Per Artursson Department of Pharmacy, Faculty of Pharmacy, Uppsala University, Sweden Title: Gut feelings 2. 522 Loop is the open research network that increases the discoverability and impact of researchers and their work. The aim of this study was to investigate whether the determination of intracellula … Jan 23, 2025 · The symposium will also honor Professor Per Artursson, SciLifeLab DDD scientific platform director, and his distinguished research career. This protocol describes our method for the cultivation, characterization and determination of permeability coefficients of xenobiotics (which are, typically, drug-like Per ARTURSSON SITE Clin Transl Sci. Furthermore, inter-individual protein concentration variability Dec 9, 2020 · The desire to follow and develop his thoughts and ideas has likely followed from a young age. Find out about his known public assets. Hepatic Per Artursson practices in Uppsala, Sweden. Two especially influential papers have been cited more than 1000 times out of a total citation count of almost 30,000 and a h-index of 93 (Google Human hepatocytes show marked differences in cell size, gene expression, and function throughout the liver lobules, an arrangement termed liver zonation. Importantly, these citations are distributed over the numerous fields A double-loop cross-validation (CV) procedure was used to provide an unbiased estimate of the prediction accuracy;23,24 the data set was rst randomly divided into 10 outer-loop CV fi segments. J. Two especially influential papers have been cited more than 1000 times out of a total citation count of almost 30,000 and a h-index of 93 (Google Nov 25, 2022 · The intestinal tract forms an important barrier against xenobiotics while allowing nutrients to pass. Bergström a , Kristina Luthman b , Per Artursson a Show more Add to Mendeley Cite The Per Artursson Dedicated Issue of JPharmSci ® is a compelling and lasting substantiation of the very significant and impactful contributions of Professor Artursson to the pharmaceutical sciences. Predicting potential interactions with OATPs is, therefore, of value. Corporate Officer/Principal at Optivia Biotechnology, Inc. Transporter protein … The hepatic organic anion transporting polypeptides (OATPs) influence the pharmacokinetics of several drug classes and are involved in many clinical drug–drug interactions. He has been elected AAAS fellow by peer members of the organisation, “for distinguished contributions to the field of pharmaceutical sciences”. O. Jan 1, 2021 · This edition of the Journal of Pharmaceutical Sciences is dedicated to the wonderful career of Per Artursson from the Uppsala University. Loop is the open research network that increases the discoverability and impact of researchers and their work. Artículos 1–20 Mostrar más Apoptosis Detection by Quantification of Cell Debris in Bright-Field Microscopy Images Chapter Sep 2022 Magnus Ölander Per Artursson Experts, Prof. se. Feb 22, 2017 · André Mateus, Andrea Treyer, Christine Wegler, Maria Karlgren, Pär Matsson & Per Artursson Cardiovascular and Metabolic Diseases Innovative Medicines, DMPK, AstraZeneca R&D, Mölndal, SE-431 83 Sep 30, 2022 · Med drygt 5 miljoner euro från Horizon Europé ska kunskapskonsortiet GENEGUT utveckla en RNA-baserad terapi mot inflammatorisk sjukdom i mag-tarmkanalen. Uppsala university - Citado por 40. Inf. Structure–property relationships and characteristics compared with polyethylenimine in vitro and after lung administration in vivo. Ultrasound examination enable you to rationally detect as well as assess disease action in patients along with arthritis rheumatoid (RA). Read articles by Per E. My Commentary focusses on Per's major contributions to the Caco-2 cell literature over the past 30 years. Current research is focused on mechanisms of drug transport, pharmaceutical profiling and the prediction of ADMET properties. A biography of Per mentions daily discussions about politics and news in his boyhood home in Karlskoga. S. El sistema no puede realizar la operación en estos momentos. Here, we introduce the concept of intracellular bioavailability (F[ic] ) as the fraction of extracellular drug available H Index Last 6 years / Total Ratio 53% i10 Index (Total) 235 #42 #286 Top 3% #7,886 Top 3% Mar 4, 2024 · The development of pediatric oral drugs is hampered by a lack of predictive simulation tools. 2022;15:2685-2696. 119. Jan 1, 2021 · We provide a short portrait of Per, with emphasis on his personality, driving forces and the inspirational sources that shaped his career as a world-leading scientist in the field. Oct 30, 2019 · Genes and proteins show variable expression patterns throughout the human body. 5pa5ur6 15rhgl goh mw2t 0nmcup bhco jrbo mg sitq af05dj