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Antisecretory agents list. AI generated definition based on .
- Antisecretory agents list. These include loperamide (Imodium), bismuth subsalicylate (Pepto-Bismol), [1] diphenoxylate with atropine (Lomotil), and opiates such as paregoric, tincture of opium, codeine, and morphine. With anti-secretory agents, the drug interaction mechanism most likely to result in adverse effects is the inhibition of Name Hypolipidemic Agents Accession Number DBCAT000274 Description Substances that lower the levels of certain LIPIDS in the BLOOD. Drugs Acting on Digestive System Antidiarrhoeals Intestinal Antiseptics These agents are used to treat severe diarrhoeal forms, which are due to microbial infection. B. The general basis of treatment with antisecretory agents is to maintain gastric pH >4 for a substantial proportion of the 24-hour cycle. Antisecretory drugs In the gastrointestinal system, anti-secretory drugs are used to decrease acid secretion in the stomach. 1. Their antiproliferative activity has been established in the phase 3 PROMID and CLARINET trials. To date, no drug meets all Antisecretory agents Gen characteristics: First-choice drug, All promote healing by suppressing secretion of gastric acid, All four are equally effective, Serious ADRs are uncommon ANTICHOLINERGIC DRUGS Which block the actions of Ach on autonomic effectors and in the CNS; exerted through muscarinic receptors. The aim was to investigate the relationship between antisecretory effect in the two populations. While proton pump inhibitors appear to have some direct effect on H. Select agents based on the balance of benefits vs. The number of hours the pH is >4. Anticholinergics are a broad group of medicines that act on the neurotransmitter, acetylcholine. Study with Quizlet and memorize flashcards containing terms like H2 receptor blockers proton pump inhibitors muscarinic antagonists prostaglandin E1 analogues, TIDINE, strong inhibitor of cytochrome p450 and more. Among antisecretory agents, we focused on all PPIs, particularly inhibiting PPIs. Abstract Thirty published studies of the clinical pharmacology of gastric antisecretory agents in normal volunteers and duodenal ulcer patients were reviewed. What does antisecretory mean? Feb 8, 2019 · PDF | H2 antagonists, also called H2 blockers, are a class of medications that block the action of histamine at the histamine H2 receptors of the | Find, read and cite all the research you need . These medications find widespread application in the treatment of conditions associated with heightened gastric acid secretion, encompassing gastroesophageal reflux disease (GERD), peptic ulcers, and heartburn. cimetidine and famotidine. It is for the antisecretory and antiperistaltic effects that the antimuscarinic agents have been advocated for the medical management of gastrointestinal obstruction. Use of a proton pump inhibitor (PPI) agent is typically preferred to a H2 antagonist. Jan 1, 2019 · Second-line agents used for treatment of diarrhea in patients with SBS include narcotics (antimotility), octreotide (antisecretory), clonidine (antisecretory), and pancreatic enzymes and bile acid replacement therapy used for treatment of fat malabsorption. Abstract Antisecretory drugs such as histamine H₂-receptor antagonists and proton pump inhibitors are commonly used for the treatment of upper gastrointestinal mucosal lesions induced by nonsteroidal anti-inflammatory drugs (NSAIDs). By blocking the action of acetylcholine, anticholinergics prevent impulses from the parasympathetic nervous system from reaching smooth muscle and causing contractions, cramps or spasms. Thirty published studies of the clinical pharmacology of gastric antisecretory agents in normal volunteers and duodenal ulcer patients were reviewed. 0 is considered an efficacy measure of the inhibition of acid secretion. H2-receptor antogonists Preferred List FAMOTIDINE BNF Link Aug 25, 2024 · ANTISECRETORY AGENTS :: These are the drugs that suppress HCI secretion by blocking receptors (muscarinic receptor blockers H2 -receptor blockers) or post receptor mechanisms like H+k+ATPase pump (proton pump inhibitors) Feb 4, 2022 · ContentsAntisecretory agent Contents Antisecretory agent • H 2 -receptor antagonist – Mechanism – Pharmacological action – ADR – ADME – Uses • Proton pump inhibitors – Mechanism – Pharmacological action – ADR – ADME – Uses Objectives At the end of this lecture, student will be able to • Explain the pharmacology of H 2 -receptor antagonist • Describe the pharmacology There are several classes of antisecretory drugs - antacids neutralize acid, H2 receptor antagonists and proton pump inhibitors decrease acid secretion, and mucosal protective agents protect the lining. H2RAs were introduced into practice first, but nowadays PPIs are more used due to their greater potency and relatively good safety profile. Unfortunately, there are few effective agents Oct 3, 2025 · Medication Summary Antisecretory medications are generally used for the treatment of acid-peptic stricture of the esophagus. pylori and extreme hypochlorhydria has a deleterious effect on the organism, the most likely mechanism by which an … Antimotility agents for the treatment of acute noninfectious diarrhea in critically ill patients: A practice management guideline from the Eastern Association for the Surgery of Trauma The role of antisecretory drugs for the prevention of upper gastrointestinal bleeding in patients using anticoagulants is unclear. Antacids These agents neutralize gastric acid and reduce pepsin activity (which diminishes as gastric pH rises to > 4. Jan 23, 2025 · The list of antisecretory agents is quite extensive. Treatment is for one week with a proton pump inhibitor or an antacid (or antisecretory agents), and two appropriate antibacterial agents. 0, pepsinogen is activated to pepsin, which can exacerbate Abstract Pharmacologic management of peptic ulcer disease continues to evolve with the introduction of diverse types of new therapeutic agents. We investigated this question in a systematic review and meta-analysis. Despite the greater antisecretory activity of PPIs compared to H 2 RAs, their efficacy is variable, depending on the degree to which the clinical manifestations of the disease are more or less attributable to acid. 22 Hypersecretion causes an increase in acidic fluid volume entering the small bowel and contributes to diarrhea and fat maldigestion for the reasons stated previously. Inhibition of gastric acid secretion may decrease the gastrointestinal absorption of drugs such as ketoconazole that dissolve poorly in the absence of adequate acid. Drugs Antimotility and antisecretory agents A number of antimotility agents are available for the symptomatic relief of diarrhea. Cholinergic Blocking agents SAR: Feb 14, 2023 · Antisecretory-antispasmodics Quaternary comps. This may not be the complete list of references from this article. They have no effect on the agent (s) that cause diarrhea, but merely alleviate the condition. Antisecretory Agents Racecadotril – Reduces intestinal secretion by acting on enkephalinase (DOC in pediatric acute diarrhoea – Sparsh Gupta) Bismuth Subsalicylate – Anti-inflammatory and mild antimicrobial Anticholinergics – Reduce motility and secretion (e. If everyday bodily functions cause you pain, these medications could help. H2RAs are well absorbed after oral dosing; peak serum concentrations occur within one to three hours. Long-term PPI therapy (almost indefinitely) is extremely important in patients with esophageal stricture. The ideal aims of treatment of peptic ulcer disease are to relieve pain, heal the ulcer, and delay ulcer recurrence. Study with Quizlet and memorize flashcards containing terms like Antisecretory agents - Octreotide (Sandostatin) - Bismuth subsalicylate (Pepto-Bismol®, Kaopectate®), Antisecretory: Octreotide (Sandostatin) MOA: blocks release of 5-HT & other peptides Use: severe secretory diarrhea due to cancer chemo, HIV, DM, GI tumors - SubQ in 2-4 divided doses - Long-acting option for long-term use ADRs Oct 13, 2025 · ANTISECRETORY AGENTS Histamine-2 receptor antagonists Mechanism of action — Histamine-2 receptor antagonists (H2RAs) (eg, cimetidine, famotidine, and nizatidine) inhibit acid secretion by blocking H2 receptors on the parietal cell (figure 1). Source for information on antisecretory drug: A Dictionary of Nursing dictionary. National Center for Biotechnology Information Jun 30, 2015 · Most of the current and historical therapeutics used for symptomatic treatment are classed as antimotility agents or antisecretory agents based on their mechanism of action (Table 1). Antidiarrheals Chapter 29 Antidarrheals Click the card to flip 👆 Antisecretory agents: Bismuth subsalicylate: Pepto-Bismol, Pink Bismuth, OTC Click the card to flip 👆 1 / 9 Histamine blockers, known as H2 blockers, and proton-pump inhibitors (PPIs) belong to the categories of drugs used to mitigate or hinder the production of stomach acid. 5 Introduction Antisecretory drugs are used for acid-related gastrointestinal disorders (see also Chap. Compare H2 antagonists (H2 blockers). Jun 30, 2022 · Out of these synthetic compounds, according to their various therapeutic uses, they have been segregated into mydriatics (cyclopentolate), antisecretory, and antispasmodics (propantheline, oxyphenonium, dicyclomine, and pirenzepine) and also antiparkinson’s drugs (trihexyphenidyl, procyclidine, and biperiden). Nov 22, 2016 · Antisecretory Agents Gastric acid hypersecretion occurs for 6 to 12 months after the resection of more than 50% of the small bowel. 1,2 However, the potential for more rapidly acting, acid-stable, and/ or increasingly potent antisecretory agents 3 to mitigate some limitations of The need for new acid suppressing agents with improved pharmacology and superior antisecretory effects to address unmet clinical needs in acid-related disorders has been evident for over a decade. any drug that reduces the normal rate of secretion of a body fluid, usually one that reduces acid secretion into the stomach. Antisecretory agents can relieve these symptoms, even in the absence of surgical or mechanical intervention. Antacids relieve symptoms, promote ulcer healing, and reduce recurrence. Oct 25, 2025 · Any drug that reduces the normal rate of secretion of a body fluid, usually one that reduces acid secretion into the stomach. Sep 1, 2007 · Although antisecretory therapy has advanced dramatically since the introduction of cimetidine in the mid-1970s, there are several identifiable unmet needs especially in the management of gastro-oesophageal reflux disease (GERD), where an antisecretory therapy with rapid onset of action and sustained antisecretory effect would be desirable [3]. Table 1. Newer antisecretory agents, which act more physiologically to reduce the loss of fluids and salt, appear to have a bright future in this area. Dec 7, 2022 · Clonidine inhibits intestinal fluid secretion by stimulating alpha-adrenergic Tips for Use of Antisecretory Agents: An antisecretory agent should be initiated immediately following extensive small bowel resection and maintained for at least 6 months. Favorable eradication data for vonoprazan were released in February 2015, and this has been the antisecretory agent of choice since March 2015. They are used to treat HYPERLIPIDEMIAS. 15 It is hydrolyzed to salicylic acid in the stomach, which helps to reduce intestinal inflammation. This study was aimed to assess the prescribing patterns and the safety of ranitidine and proton pump inhibitors (PPIs) in a cohort of Italian pediatric patients. (2) Receptor activation of parietal cell function is mediated by cyclic AMP-dependent (histamine) and calcium-dependent (cholinergic agents and gastrin) mechanisms. In addition, some antacids adsorb pepsin. undesirable effects (examples: guaifenesin may worsen nausea; scopolamine dries/thickens secretions, causes dry mouth, and sedation, which may or may not be desirable). References Aboussouan LS. 27). Anesthetic Pharmacology - March 2011A summary is not available for this content so a preview has been provided. Avoid antisecretory agents in patients with thick secretions. Examples include histamine 2 receptor antagonists, proton pump inhibitors, and somatostatin analogs like octreotide. Patients with SBS often require doses that are higher than those used for treatment of reflux disease due to malabsorption. Gastro-intestinal system 1. Apr 21, 2025 · These bind toxins and excess water in the intestine. H pylori agents involve a combination of antibacterial and antisecretory agents. Jan 21, 2025 · Mucosal protective agents can facilitate duodenal and gastric ulcer healing, though they are often adjuncts to antisecretory therapies (PPIs/H2 antagonists) or used in specific contexts such as NSAID ulcers (misoprostol) or simpler regimens for mild duodenal ulcers (sucralfate). They mainly comprise of certain members of the sulphonamides and antibiotics that are poorly absorbable in the GIT, and thus, reach in high concentrations to the small and large bowels. Thus, the tissue damaged because of the infection has time to heal. Jun 10, 2025 · Overview of proton pump inhibitors, their uses, and potential adverse effects in managing acid-related disorders. Compared to the group of absorbable drugs, non-absorbable ones are more effective, and the spectrum of undesirable effects arising from them is much narrower. Antimicrobial agents eliminate the Helicobacter pylori, whereas antisecretory agents reduce the acid production from the stomach. Dec 28, 2024 · Antisecretory agents are medications designed to suppress gastric acid secretion, playing a crucial role in treating conditions like peptic ulcers. PPIs and H2 -receptor antagonist are considered first-line antisecretory agents to treat gastric acid hypersecretion that occurs following extensive intestinal resection. However, despite their effectiveness, PPIs display some intrinsic limitations, which underlie the unmet clinical needs that have been identified over the past decades. The fundus serves as the reservoir for ingested meals, while the distal stomach churns and mixes with digestive enzymes and initiates the digestive process. Unlike loperamide and other opioids, it is said to have only antisecretory properties. Effect of Antisecretory Drugs and Nitrates on the Risk of Ulcer Bleeding Associated With Nonsteroidal Anti-Inflammatory Drugs, Antiplatelet Agents, and Anticoagulants The role of antisecretory drugs for the prevention of upper gastrointestinal bleeding in patients using anticoagulants is unclear. Antisecretory antispasmodic used in combination with benzodiazepines for nervous dyspepsia, gastritis, irritable bowel syndrome, colic, peptic ulcer PIPENZOLATE METHYL BROMIDE 5–10 mg (children 2–3 mg) oral Promoted especially for flatulent dyspepsia, infantile colics and abdominal cramps Dicyclomine 20 mg oral/i. Among the drugs available to inhibit acid secretion, proton pump inhibitors (PPIs) have been shown to have the best benefit-risk ratio and have been used widely. The antisecretory action of prostaglandins reflect interference with histamine activation of adenylate cyclase. Cholinergic receptors are usually categorized as nicotinic or muscarinic. Sep 1, 2022 · Hypovolemic shock refers to a medical or surgical condition in which rapid fluid loss results in multiple organ failure due to inadequate circulating volume and subsequent inadequate perfusion. Treatment for a gastric ulcer caused by H. A variety of potential targets for antisecretory agents have been explored which include loci within the enterocyte (the chloride channel, calcium-calmodulin) and other sites such as enteric nerves and endogenous mediators (such as 5-HT, prostaglandins). Download Table | Pharmacologic agents available for the treatment of noninfectious diarrhea from publication: Crofelemer, a novel antisecretory agent approved for the treatment of HIV-associated During the last 5 years important advances have occurred in the control of gastric acid hypersecretion in Zollinger-Ellison syndrome (ZES). One such product is 2-Aminoacetophenone, which has various applications in chemical synthesis. Aug 15, 2024 · Purpose of the Review Acid suppression with proton pump inhibitors (PPIs) represents the standard of care in the treatment of acid-related diseases. We searched Embase, PubMed, Web of Science, Scopus, Oct 16, 2024 · Introduction Somatostatin analogs (SSAs) were developed as antisecretory agents to palliate hormonal symptoms in patients with functioning neuroendocrine tumors (NETs). g. Feb 16, 2017 · The antisecretory agent was chosen by the physician in charge. Selected References These references are in PubMed. Nonabsorbable antacids can be roughly classified into three subgroups: Having aluminum phosphate as an active ingredient. Oct 11, 2025 · Anatomic structures of the stomach are divided into the cardia, fundus, body, and pylorus. Dec 30, 2024 · Antidiarrheal agents include several drug classes, including opioid agonists, somatostatin analogues, adsorbents, and bile acid sequestrants. Antisecretory drugs and mucosal protectants 1. Of this group of agents, loperamide is the most active and will reduce the symptoms of diarrhea by 60%. Feb 9, 2025 · Antisecretory drugs are used for acid-related gastrointestinal disorders (see also Chap. The gastrointestinal system is host to an extremely wide range of diseases and disorders, that include digestive disorders, GI tract motility issues, cancers of GI tract tissues, gastroenteritis, dyspepsia, gastro-oesophageal reflux disease, peptic ulcers, infections, haemorrhoids, diverticular disease, polyps, and inflammatory bowel diseases amongst many others. By including relevant studies, we would like to elucidate a recent role of antisecretory agents for gastric ESD in terms of prevention of ulcer bleeding and possible advantages on ulcer healing. However, it has recently been reported that these drugs exacerbate NSAID-induced small intestinal lesions in rats. This one week triple therapy does give a good eradication rate. Most of the current and historical therapeutics used for symptomatic treatment are classed as antimotility agents or antisecretory agents based on their mechanism of action (Table 1). Racecadotril (acetorphan) has been proposed as such an agent. Anticholinergics often demonstrate differential antagonism for different receptors types and subtypes, accounting in part for their Looking for online definition of antisecretory in the Medical Dictionary? antisecretory explanation free. The safety of antisecretory drugs is broadly summarized with reference to several recent comprehensive reviews and set within the clinical context of patient management, particularly those on long-term treatment who are the greatest risk of some adverse events. Treatment depends on whether Abstract Antisecretory agents may affect the absorption, metabolism, and renal excretion of other drugs. PPIs are the most efficacious drugs, and this class is usually used routinely. In order to understand Antimuscarinic drugs properly, it's required to classify them according to their chemistry. Somatostatin analogues are particularly helpful for secretory diarrhea due to endocrine hormone-producing malignancies, while bile acid sequestrants can be used for Full Text The Full Text of this article is available as a PDF (77K). 1. Please use the Get access link above for information on how to access this content. List of H 2 -Receptor Antagonists and Proton Pump Inhibitors Used for Treatment of GERD Jan 21, 2025 · Treatment of acid-related diseases using potassium-competitive acid blockers Temporal trends in use of antisecretory agents among patients administered clopidogrel-based dual antiplatelet therapy after percutaneous coronary intervention Antisecretory agents (H 2 receptor antagonists [H 2 RAs] and proton pump inhibitors [PPIs]) inhibit gastric acid secretion and raise intragastric pH decreasing the damaging potential of the refluxate. They are also called antispasmodics. 16 Bismuth subsalicylate has some limitations including: frequency of administration (every 30-60 minutes, up to 8 Study with Quizlet and memorize flashcards containing terms like Antisecretory/blocking agents action, Antisecretory/blocking: Proton pump inhibitors (PPI), Antisecretory/blocking agents: Histamine receptor antagonsits and more. Indeed, a wide range of anticholinergic agents such as atropine, scopolamine, or their quaternary ammonium salts, inhibit perspiration, but the many side effects they produce forfeit their use as antiperspirants. The efficacy of antibiotics against Helicobacter pylori is enhanced by the co-administration of antisecretory drugs. These medications mainly work through antimotility and/or antisecretory effects. Anticholinergics are used in the treatment of some gastrointestinal and PPIs should not be administered concomitantly with H2-antagonists, prostaglandins or other antisecretory agents owing to the marked reduction in their acid inhibitory effects when administered simultaneously; however, sufficient time interval between administration of the H2 antagonist and the PPI is recommended when there is a need of Agents used in treatment of Helicobacter Pylori are medicines used for stomach acid inhibition, combined with antibacterial agents. These medical management approaches are outlined, and recommendations are made. Examples are sulphasalazine, sulphaguanidine Antisecretory agents There is an ongoing search for the ideal antisecretory agent—that is, a drug that will directly inhibit secretory processes within the enterocyte. Drugs Study with Quizlet and memorize flashcards containing terms like what substances cause mucosal erosions or ulcerations?, what is the most common cause of peptic ulcers?, what are the treatment options for peptic ulcer disease? and more. Jul 8, 2022 · An antisecretory agent should be initiated immediately following extensive small bowel resection and maintained for at least 6 months. SSAs currently represent the standard first-line therapy for the majority of well-differentiated G1/G2 gastroenteropancreatic NETs May 21, 2024 · Antisecretory agent use was investigated in patients undergoing clopidogrel-based DAPT. The most widely used are codeine phosphate, loperamide, diphenoxylate and kaolin/opiate preparations: proprietary formulations of these are available over the counter in many countries. Apr 26, 2021 · Antidiarrheal Agents Class Summary Antidiarrheal agents may have antisecretory and antimicrobial action. The increased availability of potent gastric acid antisecretory agents such as histamine H2-receptor Jul 23, 2024 · Antispasmodics treat cramps and spasms of the muscles inside your organs. View important safety information, ratings, user reviews, popularity and more. Most often, hypovolemic shock is secondary to rapid blood loss (hemorrhagic shock). Jul 7, 2017 · Anticholinergics are agents that decrease or block the actions of acetylcholine on its parasympathetic nervous system receptors on smooth muscle cells, glands and the central nervous system. The iden-ti cation of synthetic small molecules and potent natural fi products, and the repurposing of existing medications, present a promising preclinical pipeline of drug candi Antimotility agents are drugs used to alleviate the symptoms of diarrhea. from publication: Formulation of Dosage Forms with Proton Pump Inhibitors: State of the Art, Challenges and Future Perspectives Antisecretory agents help regulate secretion processes in the body, and Antiseptic Agents are used to prevent infections. AI generated definition based on Name Antidiarrheals Accession Number DBCAT001158 (DBCAT003732) Description Miscellaneous agents found useful in the symptomatic treatment of diarrhea. Apr 10, 2025 · ANTISECRETORY AGENTS Histamine-2 receptor antagonists Mechanism of action — Histamine-2 receptor antagonists (H2RAs) (eg, cimetidine, famotidine, and nizatidine) inhibit acid secretion by blocking H2 receptors on the parietal cell (figure 1). The aims of this review are to summarize the current status and future antisecretory drug (anti-si-kree-tŏri) n. Drug families include: Histamine H2 receptor antagonists are used to treat functional dyspepsia and to promote healing of NSAID-associated ulcers e. This category includes Proton Pump Inhibitors and H2 receptor antagonists, both of which effectively reduce the production of gastric acid. Loperamide and diphenoxylate-atropine are considered first-line antimotility agents and are typically used in combination with an antisecretory agent. m. Download scientific diagram | Antisecretory drugs [5,6,9-11,13-18]. When an antisecretory agent was prescribed at least for one day during the window period, it was regarded as concurrent use. Gastrointestinal obstruction is associated with nausea, vomiting, and abdominal pain. Antisecretory agents are compounds, such as bismuth and racecadotril, that reduce gastrointestinal secretions and have been investigated for their potential to alleviate conditions like diarrhea. , atropine, dicyclomine) ANTISECRETORY AGENTS Histamine-2 receptor antagonists Mechanism of action — Histamine-2 receptor antagonists (H2RAs) (eg, cimetidine, famotidine, and nizatidine) inhibit acid secretion by blocking H2 receptors on the parietal cell (figure 1). Bismuth salicylate is an OTC antisecretory agent aimed at reducing water and electrolyte loss secondary to prolonged diarrhea. – Propantheline, Oxyphenonium, Clidinium, Pipenzolate methyl bromide, Isopropamide, Glycopyrrolate, Tertiary amines – Dicyclomine, Valethamate, Pirenzepine Related Links Classification of Cholinergic drugs Reference CLASSIFICATION OF DRUGS- KD Tripathi Study with Quizlet and memorize flashcards containing terms like What are the different anti-diarrhea agents?, What are the antisecretory agents?, When do you use pepto bismol? and more. Codeine and Morphine Both codeine and morphine can be used as antimotility and antisecretory agents in patients with SBS as both compounds bind to the opioid receptors in the GI tract leading to decreased GI secretion and increased orocecal transit time. By lowering acid secretion, these agents help manage symptoms and promote healing in the gastrointestinal Conclusions Antisecretory drug therapy has considerable poten-tial in reducing morbidity and mortality associated with infectious, drug-induced, and other diarrhea. pylori includes a combination of medications, such as antibiotics (Clarithromycin), antisecretory agents (H2 receptor antagonists (Ranitide) and proton In theory, an antisecretory agent without an antimotility effect or significant side effects may have a role. Antacids may interfere with the absorption of other medications (eg, tetracycline, digoxin, iron). What is antisecretory? Meaning of antisecretory medical term. , children 5–10 mg Antisecretory agents are defined as medications that reduce gastrointestinal secretion and motility, commonly used to manage conditions such as gastric hypersecretion and diarrhea, particularly in patients with short bowel syndrome (SBS). Apr 6, 2015 · See Tables 1 and 2 for clinical considerations and cost when prescribing opium tincture. 0). Such drugs include antimuscarinic drugs, H2-receptor antagonists (see antihistamine), and proton-pump inhibitors. AI generated definition based on: Paediatrics and Child Health, 2012 Jan 3, 2023 · Antisecretory drugs are frequently used in the treatment of pediatric gastrointestinal disorders. Proton pump inhibitors (PPIs) have demonstrated good efficacy with excellent safety profiles for indications across acid peptic disorders, with widespread availability and use in clinical practice. Recent new antisecretory drugs (IR-omeprazole and Jan 5, 2016 · Antisecretory agents Class Summary These agents have vasoconstrictive properties and can reduce blood flow to portal systems. This article provides a broad perspective on the pharmacology and therapeutic actions of antiulcer drugs. When intragastric pH <4. 26, 27 Intracellular signalling mechanisms were an initial pharmacological target, especially those related to calcium and the calcium binding protein calmodulin. 3. For example, their local antisecretory activity was long thought to be beneficial for inhibiting eccrine sweating (perspiration) [70]. dro xvm5 qear agyze466 xziimua wyq kersg vfgq8xd vd 3iez